Didn't specify what kind/which subject matter, so I'll just recommend Watchmen and Maus off the top in case you haven't read them already.
Some graphic novels I've found personally significant:
Fun Home
I Kill Giants
Blankets
Plus I'm working on one rn so I gotchu
Seconds, it’s by the guy who did Scott Pilgrim
Superman For All Seasons (really pretty art, not crazy comic book-y)
The Underwater Welder (kinda X-Files ish)
King City is a really awesome one. it's goofy and smart like adventure time, but also really adult at the same time.
some flavor pages:
bone if you haven’t already
Sooo like yea
So none of you motherfuckers gonna say Watchmen or what??? Read Watchmen op, its pretty good.
we had to do assignments on 'maus' at school cant rember if it was good was to busy trying to reach 1500 words
Seconds, it’s by the guy who did Scott Pilgrim
Superman For All Seasons (really pretty art, not crazy comic book-y)
The Underwater Welder (kinda X-Files ish)
wow i don’t think ive ever met anyone else who likes superman for all seasons